Effectiveness Of Topical Tirbanibulin For Lentigo Maligna: A Case Series Of Eight Patients And Biological Insights

Effectiveness Of Topical Tirbanibulin For Lentigo Maligna: A Case Series Of Eight Patients And Biological Insights

Authors

  • Andrea Agostini Mauriziano Umberto Hospital, Dermatology and Venereology, Medical Sciences, Turin
  • Martina Merli Mauriziano Umberto Hospital, Dermatology and Venereology, Medical Sciences, Turin
  • Paola Calamaro Mauriziano Umberto Hospital, Anatomical Pathology, Medical Sciences, Turin
  • Paolo Broganelli Mauriziano Umberto Hospital, Dermatology and Venereology, Medical Sciences, Turin

Keywords:

Lentigo maligna, Tirbanibulin, Melanoma

References

Robinson M, Primiero C, Guitera P, et al. Evidence-Based Clinical Practice Guidelines for the Management of Patients with Lentigo Maligna. Dermatology. 2020;236(2):111-116. DOI:10.1159/000502470

Vaienti S, Calzari P, Nazzaro G. Topical Treatment of Melanoma In Situ, Lentigo Maligna, and Lentigo Maligna Melanoma with Imiquimod Cream: A Systematic Review of the Literature. Dermatol Ther (Heidelb). 2023;13(10):2187-2215. DOI:10.1007/s13555-023-00993-1

Blauvelt A, Kempers S, Lain E, et al. Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis. N Engl J Med. 2021;384(6):512-520. DOI:10.1056/NEJMoa2024040

Schlesinger T, Stockfleth E, Grada A, Berman B. Tirbanibulin for Actinic Keratosis: Insights into the Mechanism of Action. Clin Cosmet Investig Dermatol. 2022;15:2495-2506. Published 2022 Nov 16. DOI:10.2147/CCID.S374122

DeWane ME, Kelsey A, Oliviero M, Rabinovitz H, Grant-Kels JM. Melanoma on chronically sun-damaged skin: Lentigo maligna and desmoplastic melanoma. J Am Acad Dermatol. 2019;81(3):823-833. DOI:10.1016/j.jaad.2019.03.066

Park J, Kang M, Lim A, et al. Synthesis and evaluation of tirbanibulin derivatives: a detailed exploration of the structure-activity relationship for anticancer activity. RSC Adv. 2023;13(50):35583-35591. Published 2023 Dec 6. DOI:10.1039/d3ra06790d

Published

2026-04-30

How to Cite

1.
Agostini A, Merli M, Calamaro P, Broganelli P. Effectiveness Of Topical Tirbanibulin For Lentigo Maligna: A Case Series Of Eight Patients And Biological Insights. Dermatol Pract Concept. 2026;16(2). doi:10.5826/dpc.1602a6845

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