Hypomelanotic melanoma detected by the “little red riding hood sign” in a patient with neurofibromatosis type 1

Roberta Giuffrida; Maximilian Uranitsch; Karin Schmid; Teresa Deinlein; Fabrizio Favero; Iris Zalaudek

doi:10.5826/dpc.0704a14

Hypomelanotic melanoma detected by the “little red riding hood sign” in a patient with neurofibromatosis type 1

Authors

Roberta Giuffrida Department of Clinical and Experimental Medicine, section of Dermatology, University of Messina, Messina, Italy http://orcid.org/0000-0002-5492-3033
Maximilian Uranitsch Department of Dermatology and Venereology, University of Trieste, Ospedale Maggiore, Trieste, Italy
Karin Schmid Department of Physiology, Medical University of Graz, Graz, Austria
Teresa Deinlein Department of Dermatology and Venereology, University of Trieste, Ospedale Maggiore, Trieste, Italy
Fabrizio Favero Department of Dermatology and Venereology, University of Trieste, Ospedale Maggiore, Trieste, Italy
Iris Zalaudek Department of Dermatology and Venereology, University of Trieste, Ospedale Maggiore, Trieste, Italy

Keywords:

neurofibromatosis type 1, melanoma, dermoscopy

Abstract

Neurofibromatosis type 1 (NF1) is a genetic disorder commonly associated with an increased risk for development of malignancy, including skin cancers. Herein we describe a case of invasive melanoma occurring in a patient with NF1 and discuss the association between these two diseases, highlighting the importance of comparative clinical and dermoscopic approach in this category of patients in which the detection of melanoma can be difficult by the presence of multiple skin tumors.

References

Mascaro JM Jr, Mascaro JM. The dermatologist's position concerning nevi: a vision ranging from "the ugly duckling" to "little red riding hood". Arch Dermatol. 1998 Nov;134(11):1484-5. PubMed PMID: 9828892.

Kiuru M, Busam KJ. The NF1 gene in tumor syndromes and melanoma. Lab Invest. 2017 Feb;97(2):146-157. PubMed PMID: 28067895.

Guillot B, Dalac S, Delaunay M, et al. Cutaneous malignant melanoma and neurofibromatosis type 1. Melanoma Res. 2004 Apr;14(2):159-63. PubMed PMID: 15057048.

Hernández-Martín A, Duat-Rodríguez A. An Update on Neurofibromatosis Type 1: Not Just Café-au-Lait Spots and Freckling. Part II. Other Skin Manifestations Characteristic of NF1. NF1 and Cancer. Actas Dermosifiliogr. 2016 Jul-Aug;107(6):465-73. PubMed PMID: 26956402.

Gaudy-Marqueste C, Wazaefi Y, Bruneu Y et al. Ugly Duckling Sign as a Major Factor of Efficiency in Melanoma Detection. JAMA Dermatol. 2017 Apr 1;153(4):279-284. PubMed PMID: 28196213.