Diffuse neonatal hemangiomatosis presenting as congestive heart failure
Keywords:
hemangioma, vascular tumors, neonatal, congestive heart failureAbstract
Diffuse neonatal hemangiomatosis is a rare condition with a very high mortality rate if left untreated. We report a neonate having around 490 cutaneous and multiple diffuse liver hemangiomas presenting as congestive heart failure. Prompt treatment was instituted with decongestive drugs and prednisolone for anticipated life threatening complications due to hepatic hemangiomas. Propranolol was added later as it is known to precipitate congestive failure and also to avoid long-term complications of steroids. The child responded well. However, there is no consensus regarding the initial line of management, which needs to be individualized keeping in mind the efficacy, long-term side effects of the drug and the clinical presentation.
References
Becker JM, Heitler MS: Hepatic hemangioendotheliomas in infancy. Surg Gynecol Obstet. 1989;168:189–200. PubMed
Lister WA. The natural history of strawberry naevi. Lancet. 1938;1:1429-1434.
Gottschling S, Schneider G, Meyer S, Reinhard H, Dill-Mueller D, Graf N. Two infants with life-threatening diffuse neonatal hemangiomatosis treated with cyclophosphamide. Pediatr Blood Cancer. 2006;46:239-242. PubMed CrossRef
Sommers Smith SK, Smith DM. Beta blockade induces apoptosis in cultured capillary endothelial cells. In Vitro Cell Dev Biol Anim. 2002;38:298–304. PubMed CrossRef
Takahashi K, Mulliken JB, Kozakewich HP, Rogers RA, Folkman J, Ezekowitz RA. Cellular markers that distinguish the phases of hemangioma during infancy and childhood.J Clin Invest. 1994 Jun 93(6):2357-64. PubMed CrossRef
Wananukul S, Voramethkul W, Nuchprayoon I, Seksarn P. Diffuse neonatal hemangiomatosis: report of 5 cases. J Med Assoc Thai. 2006;89:1297-1303. PubMed
Poirier VC, Ablin DS, Frank Diffuse neonatal hemangiomatosis: a case report. AJNR Am J Neuroradiol. 1990;11(6):1097-1099.
Upton A. Diffuse neonatal hemangiomatosis. 2005;21:350–353. Accessed September 13, 2016.
D’Angelo G, Lee H, Weiner RI. cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation. J Cell Biochem. 1997;67:353–366. PubMed
Gunturi N, Ramgopal S, Balagopal S, Scott JX. Propranolol therapy for infantile hemangioma. Indian Pediatr. 2013;50:307-313. PubMed
Zhou H, Li QF, Cao GL, Ling HZ, Dai HR, Chen XH. Successful treatment of diffuse neonatal hemangiomatosis with propranolol: a case report. J Dtsch Dermatol Ges. 2014 Jul;12(7):625-628. PubMed CrossRef
Dotan M, Lorber A. Congestive heart failure with diffuse neonatal hemangiomatosis—case report and literature review. Acta Paediatr. 2013;102(5):e232-238. PubMed CrossRef
Nip SY, Hon KL, Leung WK, Leung AK, Choi PC. Neonatal abdominal hemangiomatosis: Propranolol beyond Infantile Hemangioma. Case Rep Pediatr. 2016;2016:803975. PubMed CrossRef
Blanchet C, Nicollas R, Bigorre M, Amedro P, Mondain M. Management of infantile subglottic hemangioma: acebutolol or propranolol? Int J Pediatr Otorhinolaryngol. 2010;74:959-961. PubMed CrossRef
Chai Q, Chen WL, Huang ZQ, Zhang DM, Fan S, Wang L. Preliminary experiences in treating infantile hemangioma with propranolol. Ann Plast Surg. 2014;72(2):169-172. PubMed CrossRef
Published
Issue
Section
License
Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). Authors retain the copyright for their published work.
How to Cite
Share
