Toward a new classification of Lentigo maligna: easy and difficult to treat Lentigo Maligna

Toward a new classification of Lentigo maligna: easy and difficult to treat Lentigo Maligna

Authors

  • Iris Zalaudek Department of Dermatology and Venereology, University of Trieste, Ospedale Maggiore, Trieste, Italy
  • Claudio Conforti IDI-IRCCS, Dermatological Research Hospital, Department of Life Science, Health, and Health Professions, Link University of Rome, Rome, Italy
  • Danica Tiodorovic University Clinical Center of Nis, Medical Faculty, University of Nis, Clinic of Dermatovenerology, Nis, Serbia
  • Nicola Di Meo Department of Dermatology and Venereology, University of Trieste, Ospedale Maggiore, Trieste, Italy
  • Roberta Giuffrida Department of Clinical and Experimental Medicine, Dermatology, University of Messina, Messina, Italy https://orcid.org/0000-0002-5492-3033

Keywords:

lentigo maligna, classification, treatment, imiquimod

References

Longo C, Navarrete-Dechent C, Tschandl P, et al. Delphi Consensus Among International Experts on the Diagnosis, Management, and Surveillance for Lentigo Maligna. Dermatol Pract Concept. 2023 Jul 1;13(3):e2023244. DOI: 10.5826/dpc.1303a244. PMID: 37403983; PMCID: PMC10412039.

Menzies SW, Liyanarachchi S, Coates E, et al. Estimated risk of progression of lentigo maligna to lentigo maligna melanoma. Melanoma Res. 2020 Apr;30(2):193-197.

Tiodorovic-Zivkovic D, Argenziano G, Lallas A, et al. Age, gender, and topography influence the clinical and dermoscopic appearance of lentigo maligna. J Am Acad Dermatol. 2015 May;72(5):801-8.

Longo C, Sticchi A, Curti A, et al. Lentigo maligna and lentigo maligna melanoma in patients younger than 50 years: a multicentre international clinical-dermoscopic study. Clin Exp Dermatol. 2024 Jan 25;49(2):128-134. DOI: 10.1093/ced/llad325. PMID: 37758301.

Hong AM, Lo SN, Fogarty GB, et al. Radiotherapy versus imiquimod for complex lentigo maligna: A phase 3 randomized clinical trial. J Am Acad Dermatol. 2025 Jul 17:S0190-9622(25)02481-8. DOI: 10.1016/j.jaad.2025.07.028. Epub ahead of print. PMID: 40683357.

Moyer JS, Rudy S, Boonstra PS, et al. Efficacy of staged excision with permanent section margin control for cutaneous head and neck melanoma. JAMA Dermatol. 2017 Mar 1;153(3):282-288.

Barlow JO, Maize J Sr, Lang PG. The density and distribution of melanocytes adjacent to melanoma and nonmelanoma skin cancers. Dermatol Surg. 2007 Feb;33(2):199-207. DOI: 10.1111/j.1524-4725.2006.33039.x. PMID: 17300606.

von Stebut J, Mallach M, Schneider-Burrus S, et al. Rosacea is strongly associated with melanoma in Caucasians. Sci Rep. 2024 May 25;14(1):11949. DOI: 10.1038/s41598-024-62552-8. PMID: 38789467; PMCID: PMC11126582.

Barlow JO, Maize J Sr, Lang PG. The density and distribution of melanocytes adjacent to melanoma and nonmelanoma skin cancers. Dermatol Surg. 2007 Feb;33(2):199-207. DOI: 10.1111/j.1524-4725.2006.33039.x. PMID: 17300606.

Hamilko de Barros M, Conforti C, et al. Clinical usefulness of dermoscopy in the management of lentigo maligna melanoma treated with topical imiquimod: A case report. Dermatol Ther. 2019 Sep;32(5):e13048. DOI: 10.1111/dth.13048. Epub 2019 Aug 12. PMID: 31365164.

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Published

2026-01-30

How to Cite

1.
Zalaudek I, Conforti C, Tiodorovic D, Di Meo N, Giuffrida R. Toward a new classification of Lentigo maligna: easy and difficult to treat Lentigo Maligna. Dermatol Pract Concept. 2026;16(1):6969. doi:10.5826/dpc.1601a6969

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