When IL-17 Blockade Backfires: Retropharyngeal Granuloma and Petrous Bone Osteonecrosis in a Patient with Psoriasis

When IL-17 Blockade Backfires: Retropharyngeal Granuloma and Petrous Bone Osteonecrosis in a Patient with Psoriasis

Authors

  • Luca Cangialosi Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy
  • Umberto Santaniello Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy https://orcid.org/0009-0008-7728-6832
  • Michela Ortoncelli Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy
  • Pietro Quaglino Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy https://orcid.org/0000-0003-4185-9586
  • Simone Ribero Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy https://orcid.org/0000-0002-0098-1406

Keywords:

Ixekizumab, Interleukin-17, Paradoxical reaction, Psoriasis, Granulomatous disease

References

Dapavo P, Siliquini N, Mastorino L, et al. Efficacy, safety, and drug survival of IL-23, IL-17, and TNF-alpha inhibitors for psoriasis treatment: a retrospective study. J Dermatolog Treat. 2022;33(4):2352-2357. doi:10.1080/09546634.2021.1961998

Munera-Campos M, Ballesca F, Carrascosa JM. Paradoxical Reactions to Biologic Therapy in Psoriasis: A Review of the Literature. Reacciones paradójicas de los tratamientos biológicos utilizados en psoriasis: revisión de la literatura. Actas Dermosifiliogr (Engl Ed). 2018;109(9):791-800. doi:10.1016/j.ad.2018.04.003

Kirby C, Herlihy D, Clarke L, Mullan R. Sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis. BMJ Case Rep. 2021;14(2):e240615. Published 2021 Feb 22. doi:10.1136/bcr-2020-240615

Hauer L, Moztarzadeh O, Baghalipour N, Gencur J. Secukinumab Causing Medication-Related Osteonecrosis of the Jaw, in a Patient Diagnosed with Psoriasis and Rheumatoid Arthritis. Psoriasis (Auckl). 2024;14:115-120. Published 2024 Sep 23. doi:10.2147/PTT.S490982

Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239-245. doi:10.1038/clpt.1981.154

Published

2026-04-30

How to Cite

1.
Cangialosi L, Santaniello U, Ortoncelli M, Quaglino P, Ribero S. When IL-17 Blockade Backfires: Retropharyngeal Granuloma and Petrous Bone Osteonecrosis in a Patient with Psoriasis. Dermatol Pract Concept. 2026;16(2):6775. doi:10.5826/dpc.1602a6775

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