Applying RCM-Based Criteria to LC-OCT for Classifying Mucosal Melanoses: A Proof-of-Concept Study

Applying RCM-Based Criteria to LC-OCT for Classifying Mucosal Melanoses: A Proof-of-Concept Study

Authors

  • Francesco Piscazzi Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy 2Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy
  • Marco Ardigò Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy 2Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy
  • Mariano Suppa Department of Dermatology, Hôpital Erasme, HUB, Université Libre de Bruxelles, Brussels, Belgium 4Department of Dermatology, Institut Jules Bordet, HUB, Université Libre de Bruxelles, Brussels, Belgium 5Groupe d’imagerie cutanée non invasive (GICNI) of the Société Française de Dermatologie (SFD), Paris, France
  • Joseph Malvehy Universitat de Barcelona, Barcelona, Spain. 7Melanoma Unit, Dermatology Department, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain. 8Centro de Investigación Biomédica en Red de Enfermedades Raras, CIBERER, Instituto de Salud Carlos III, Barcelona, Spain.
  • Susana Puig Universitat de Barcelona, Barcelona, Spain. 7Melanoma Unit, Dermatology Department, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain. 8Centro de Investigación Biomédica en Red de Enfermedades Raras, CIBERER, Instituto de Salud Carlos III, Barcelona, Spain.
  • Javiera Perez-Anker Universitat de Barcelona, Barcelona, Spain. 7Melanoma Unit, Dermatology Department, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain.

Keywords:

Line-Field Confocal Optical Coherence Tomography, LC-OCT, Microscopy, Confocal, Mucosal melanoma, melanoses

References

Cengiz FP, Emiroglu N, Wellenhof RH. Dermoscopic and clinical features of pigmented skin lesions of the genital area. An Bras Dermatol. 2015;90(2):178–83. DOI: 10.1590/abd1806-4841.20153294

Blum A, Simionescu O, Argenziano G, et al. Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction: results of a multicenter study by the International Dermoscopy Society (IDS): Results of a multicenter study by the international dermoscopy society (IDS). Arch Dermatol. 2011;147(10):1181–7. DOI: 10.1001/archdermatol.2011.155

Debarbieux S, Perrot JL, Erfan N, et al. Reflectance confocal microscopy of mucosal pigmented macules: a review of 56 cases including 10 macular melanomas. Br J Dermatol.2014;170(6):1276–84. DOI: 10.1111/bjd.12803

Valenti M, Piscazzi F, Franceschini C, Ferrari A, Frascione P, Ardigò M. Characterizing pigmented mucosal lesions: New insights from reflectance confocal microscopy. J Eur Acad Dermatol Venereol. 2025;39(7):e638-e641. DOI: 10.1111/jdv.20656

Latriglia F, Ogien J, Tavernier C, et al. Line-field confocal optical coherence tomography (LC-OCT) for skin imaging in dermatology. Life (Basel). 2023;13(12):2268. DOI: 10.3390/life13122268

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Published

2026-04-30

Issue

Vol. 16 No. 2 (2026): 2026 Vol 16, No 2 | April

Section

Research Letter

License

Copyright (c) 2026 Francesco Piscazzi, Marco Ardigò, Mariano Suppa, Joseph Malvehy, Susana Puig, Javiera Perez-Anker

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). Authors retain the copyright for their published work.

How to Cite

1.
Piscazzi F, Ardigò M, Suppa M, Malvehy J, Puig S, Perez-Anker J. Applying RCM-Based Criteria to LC-OCT for Classifying Mucosal Melanoses: A Proof-of-Concept Study. Dermatol Pract Concept. 2026;16(2):6544. doi:10.5826/dpc.1602a6544

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